Basic Bioisosteres
Bioisosteres offer the opportunity to modulate the pKa of the basic center, to mask very hydrophilic functional groups capable of forming multiple hydrogen bonding interactions. Constrained analogues may no longer be substrates for MAO.
Many sample collections contain many, many structures containing the Piperazine motif the bioisosteric described bellow off the opportunity to modify the pKa of the nitrogens but also subtly alter the directionality of the vectors from the nitrogens.
Last Update 12 November 2011
Simple Bioisosteres
Carbonyl Bioisosteres
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