Bioisosteric Replacements

Bioisosteres - A bioisostere is a molecule resulting from the exchange of an atom or of a group of atoms with an alternative, broadly similar, atom or group of atoms. The objective of a bioisosteric replacement is to create a new molecule with similar biological properties to the parent compound. The bioisosteric replacement may be physicochemically or topologically based. The replacement can attenuate toxicity, modify activity of lead, and/or alter pharmacokinetics of lead.

Simple replacements

 1. Me NH2 OH F Cl

2. Cl PH2 SH CN

3. Br iPr CF3

4. I tBu CF3

5. CH2 NH O S

6. CO2R CONHR COSR COCH2R

7. -CH= -N= -S-

8. C Si

9. Phenyl Pyridyl Thiophene 4-Fluorophenyl

10. -OH -F -OMe

11. -O- -CF2-



Last Update 12 November 2011
Carbonyl Bioisosteres
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