Transporter interaction
Transporter-based interactions have been increasingly documented. Various reported interactions attributed earlier to other mechanisms of interaction, such as protein-displacement or enzyme inhibition/induction, may be due in part to the inhibition or induction of transport proteins, such as
- P-glycoprotein (P-gp)
- organic anion transporter (OAT)
- organic anion transporting polypeptide (OATP)
- organic cation transporter (OCT)
- multidrug resistance-associated proteins (MRP)
- breast cancer resistant protein (BCRP) Examples of transporter-based interactions include the interactions between
- digoxin and quinidine
- fexofenadine and ketoconazole (or erythromycin)
- penicillin and probenecid
- dofetilide and cimetidine Of the various transporters, P-gp is the most well understood and may be appropriate to evaluate during drug development.
Updated 17 February 2012