Transporter interaction

Transporter-based interactions have been increasingly documented. Various reported interactions attributed earlier to other mechanisms of interaction, such as protein-displacement or enzyme inhibition/induction, may be due in part to the inhibition or induction of transport proteins, such as
• P-glycoprotein (P-gp)
• organic anion transporter (OAT)
• organic anion transporting polypeptide (OATP)
• organic cation transporter (OCT)
• multidrug resistance-associated proteins (MRP)
• breast cancer resistant protein (BCRP)
Examples of transporter-based interactions include the interactions between
• digoxin and quinidine
• fexofenadine and ketoconazole (or erythromycin)
• penicillin and probenecid
• dofetilide and cimetidine
Of the various transporters, P-gp is the most well understood and may be appropriate to evaluate during drug development.






Last Update 21 Sept 2009
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