Cytochrome P450 (CYP) enzyme induction is a biological process where exposure to an administered drug increases the activity and production of liver enzymes, causing other drugs to break down faster. This results in lower systemic exposure to the drug but can also increase the clearance of any other drugs administered. This process can also reduce the exposure in safety studies compromising safety margins.

The latest OpenADMET challenge addressed one of the most important processes for enzyme induction, PXR activation. An excellent review of the results is now available.