26th symposium on Medicinal Chemistry in Eastern England (Hatfield symposium)

Thursday, 23rd April 2015 The Fielder Centre, Hatfield, Herts, UK

Speakers and Presentations Identification of orally bioavailable type 2 inhibitors of discoidin domain-containing receptor 1/2 (DDR1/DDR2) using “back-to-front” X-ray FBDD Emiliano Tamanini, Astex Therapeutics

Drug discovery towards the eradication of malaria Paul Willis, Medicines for Malaria Venture

Exploring water networks to predict binding affinity and selectivity Daniel D Robinson, Schrödinger

URAT-1 solute carrier inhibitor program for the treatment of gout Ian Storer, Pfizer

The discovery of potent brain penetrant BACE inhibitors Fionna Martin, Lilly

The monster mas agonist – revealing the beauty in the beast Simon Peace, GlaxoSmithKline

The discovery of therapeutics for neglected diseases and the translation of novel biology through small molecule drug discovery Andrew Woodland, Drug Discovery Unit, University of Dundee

A softdrug approach to PDE4 inhibitors for the topical treatment of skin diseases Nuria Aguilar, Almirall

The European Lead Factory: a pan-European approach to access new chemical space for drug discovery Adam Nelson, University of Leeds

Novel 5-HT7 antagonists, with an unprecedented selectivity profile, for the treatment of migraine Ali Ates, UCB

Sulfoximine substituted morpholino-pyrimidines for the treatment of cancer Kevin Foote, AstraZeneca

Event website www.maggichurchouseevents.co.uk/bmcs