ENABLE-2 offers evaluation of the antibiotic potential of novel compounds.

(i) Antibacterial activity (MIC) will be measured against selected Gram-negative and Gram-positive species to identify Hits (defined as compounds with wild-type whole cell activity on at least a species of interest).

(ii) Hits will be evaluated for in vitro cytotoxicity.

(iii) Limited hit expansion to explore SAR is possible if required by the programme and if ENABLE-2 resources are available.

Researchers at publicly funded universities and research institutes in Europe (including non-EU countries such as UK, Norway, Switzerland etc.) are eligible.

ENABLE-2 bacterial species of interest for Hit to Lead development

E.coli, K. pneumoniae, P. aeruginosa, A. baumannii, S. aureus, E. faecium.