ChEMBL_18 has just been released.

It can be downloaded from the ChEMBL FTP site, and there are more details on the ChEMBL blog

• 1,566,466 compound records
• 1,359,508 compounds (of which 1,352,681 have mol files)
• 12,419,715 activities
• 1,042,374 assays
• 9,414 targets
• 53,298 documents

They now include epigenetic targets, and several new web services giving drug approvals and mechanisms.