In the last few updates I’ve concentrated on Fragment-Based-Screening, where by screening a small set of low molecular weight fragments it is possible to obtain hits that can then be expanded. The latest update highlights the use of encoded libraries, here vast libraries (>>1M compounds) can be screened the hits isolated and identified by virtue of a DNA tag.

From the early “proof-of-principle” peptide libraries this area has now extended into a variety of interesting chemistries.