As 2019 starts I'd like to wish you all a Happy New Year and hope for great success in your drug discovery endeavours.

The Drug Discovery Resources website continues to increase in popularity with over 147,000 page views, an increase of 8% over the figure for 2017. The pages were visited by over 72,500 viewers and around a third of the visitors come back on multiple occasions suggesting they find it useful. The visitors come from 172 different countries with the US (32%), UK (13%) and India (8%) topping the list.

The most viewed pages in 2018 were

• Lipophilicity
• Distribution and Plasma Protein Binding
• Bioisosteres
• Calculating Physicochemical Properties
• Molecular Interactions
• Kinase Inhibitors
• Aspartic Acid Protease Inhibitors
• Solvation and desolvation
• Hit Identification
• CYP Interactions
• Acid Bioisosteres
• Fragment based screening
• HERG

There have been a number of significant updates to the Drug Discovery Resources this year, in particular, a new section on Macrocycles which has proved very popular. The Target Validation section has been updated several times, as has the Molecular Interactions page and I'm grateful for readers who have pointed out relevant recent publications.

Interestingly the Books and Grant funding research have seasonal peaks in viewing.

Looking at the operating systems 56% are Windows users, 20% Mac users, 10% iOS and 10% Android, Chrome dominates the browser stats (64%) with Safari second (17%) and Firefox third (10%).