Covalent Inhibitorrs are an increasingly investigated class of drugs. The attraction is the irreversible nature of the binding and subsequent prolonged target engagement. An invaluable resource for this area of research is the Covalent Inhibitor Database that has recently been updated to version 2.0.

This updated version includes 8303 inhibitors and 368 targets, supplemented by 3445 newly added cocrystal structures, providing detailed analyses of non-covalent interactions.

The article describing the database is here DOI.